"Glucosamine is being investigated extensively for its action in osteoarthritis. However, there is a lack of consensus in clinical trials regarding its efficacy."

"Glucosamine is a supplement that is often combined with another supplement, chondroitin to help the pain of osteoarthritis. Glucosamine is made from crab shells and chondroitin, from cow trachea. "

"Glucosamine is a natural constituent of healthy cartilage and synovial fluid in the joints of the body. It is derived from glucose and the amino acid glutamine, and as we age we tend to produce less. Our bodies use glucosamine to build and repair cartilage, tendons, ligaments, synovial fluid and other tissues. We need glucosamine primarily for the healthy structure, strength and shock absorbing functions of our joints."

"The typical initial dose is 1500 mg of glucosamine and 1200 of chondroitin daily for 1- 2 months. If a response is obtained, the dose can be reduced to 1000 mg of glucosamine and 800 of chondroitin or less."

"Glucosamine - Typical recommended therapeutic dosage is 1500 mg per day, either as a single dose or in two or three divided doses, for 30 to 90 days duration. Some studies recommend a daily glucosamine dosage of 20 mg per kilogram of body weight, which gives a more individualized approach. A preventative supplemental dosage could safely vary from 500 mg to 1500 mg per day according to the individual. Chondroitin sulphate - For injury prevention or to supplement your diet 400 mg per day is adequate. Between 800 mg and 1200 mg chondroitin daily (in two or three divided doses) is the usual recommended therapeutic dosage. Research using a regime of intermittent chondroitin sulphate supplementation, alternating 3 months treatment with 3 months break, indicates positive results for people with mild forms of osteoarthritis. When positive results are gained after one to two months on the recommended therapeutic dosage it is a good idea to then reduce your daily dosage of each by a third (to 1000 mg glucosamine and 600 - 800 mg chondroitin) and monitor your body s response. A lower daily dosage than the generally recommended one may be adequate supplementation for some individuals."